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Xanthurenic Acid

CAS No. 59-00-7

Xanthurenic Acid ( NSC 401570 | Xanthurenate )

产品货号. M15182 CAS No. 59-00-7

黄尿酸或黄尿酸盐是一种化学物质,可诱导恶性疟原虫配子发生,恶性疟原虫是引起疟疾的寄生虫。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
100MG ¥340 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Xanthurenic Acid
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    黄尿酸或黄尿酸盐是一种化学物质,可诱导恶性疟原虫配子发生,恶性疟原虫是引起疟疾的寄生虫。
  • 产品描述
    Xanthurenic acid, or xanthurenate, is a chemical shown to induce gametogenesis of Plasmodium falciparum, the parasite that causes malaria. It is found in the gut of the Anopheles mosquito. Xanthurenic acid is a metabolic intermediate that accumulates and is excreted by pyridoxine (vitamin B6) deficient animals after the ingestion of tryptophan.
  • 体外实验
    ——
  • 体内实验
    Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus. The inhibition of Xanthurenic acid (XA) on sensory can be found when applied iontophoretically and i.v., is similar to that of other Group II mGlu receptor agonists in reducing inhibition evoked in the VB from the thalamic reticular nucleus upon physiological sensory stimulation. Furthermore, it is postulated that Xanthurenic acid may be the first potential endogenous allosteric agonist for the mGlu receptors. As the Group II receptors and kynurenine metabolism pathway have both been heavily implicated in the pathophysiology of schizophrenia, Xanthurenic acid could play a pivotal role in antipsychotic research as this potential endocoid represents both a convergence within these two biological parameters and a novel class of Group II mGlu receptor ligand.
  • 同义词
    NSC 401570 | Xanthurenate
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    59-00-7
  • 分子量
    205.17
  • 分子式
    C10H7NO4
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 10 mM
  • SMILES
    OC(=O)C1=CC(=O)C2=C(N1)C(O)=CC=C2
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Haruki H, et al. J Biol Chem. 2015 Nov 12. pii: jbc.C115.680488.
产品手册
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